Thrombocytopenia
Thrombotic thrombocytopenic purpura
Acute intermittent porphyria
Sepsis
Anaphylaxis - as reaction to meds, other things, or unprovoked.
(While some people suffer anaphylaxis as part of a serious allergic reaction, in two out of three people, anaphylaxis has no known cause and thus the anaphylactic reaction is called idiopathic.)
https://www.nih.gov/news-events/news-releases/abnormal-immune-cells-may-cause-unprovoked-anaphylaxis
April 9, 2020
COVID-19: Thrombosis and Hemoglobin
https://rebelem.com/covid-19-thrombosis-and-hemoglobin/
2020 Mar 13
Thrombocytopenia is associated with severe coronavirus disease 2019 (COVID-19) infections: A meta-analysis.
06-13-18
Thrombocytopenia in the ICU: disseminated intravascular coagulation and thrombotic microangiopathies—what intensivists need to know
https://ccforum.biomedcentral.com/articles/10.1186/s13054-018-2073-2
2014 Apr
Use of the ADAMTS13 activity assay improved the accuracy and efficiency of the diagnosis and treatment of suspected acquired thrombotic thrombocytopenic purpura.
Effects of oxygen-induced lung damage on megakaryocytopoiesis and platelet homeostasis in a rat model.
Peripheral platelet and intra-pulmonary megakaryocyte counts in the lung-damaged rats were significantly lower than those in their respective controls. Intra-pulmonary thrombi or platelet aggregation were detected in the lung-damaged rats but not in the controls. These findings showed that hyperoxic lung damage reduced circulating platelets through (1) failure of the lungs to retain and fragment megakaryocytes to release platelets, and (2) platelet activation leading to platelet aggregation, thrombi formation and platelet consumption. The magnitude of platelet reduction was physiologically significant, as demonstrated by higher counts of megakaryocyte colony forming units in the bone marrow culture of the animals in the hyperoxia group when compared with the controls.
https://www.ncbi.nlm.nih.gov/pubmed/12815110
Lung damage may induce thrombocytopenia.
https://www.ncbi.nlm.nih.gov/pubmed/16928610
Coagulation, Fibrinolysis, and Fibrin Deposition in Acute Lung Injury
What Are The Risk Factors With Thrombotic Thrombocytopenic Purpura?
It isn't clear what triggers inherited and acquired TTP, but some factors may play a role. These factors may include:
COVID-19 and Rare Hematological Diseases
https://www.eurobloodnet.eu/covid/covid-19-information/
Tips for the Undiagnosed
https://rarediseases.info.nih.gov/guides/pages/24/tips-for-the-undiagnosed
More Than Surviving Sepsis: Everything Old Is New Again
JUN 03, 2019 | LAUREN A. IGNERI, PHARMD, BCPS, BCCCP
https://www.evms.edu/pulse/archive/newsepsistreatmentcatchingondespiteconflictingresearch.php
New sepsis treatment catching on despite conflicting research
Fri, 14 Feb 2020 13:48:00 EST
By EVMS News
Paul Marik, MD, a highly respected physician who is Chief of Critical Care at EVMS and Professor of Internal Medicine, came up with his treatment in a hail-Mary attempt to save a patient dying of septic shock in January 2016. He combined hydrocortisone, ascorbic acid (vitamin c) and thiamine, a combination now commonly known by the moniker HAT.